Guestbook

Peterfew

02 Apr 2025 - 06:32 am

Exposure to phthalates during pregnancy can affect a newborn’s brain development, study finds
порно анальный секс

Phthalates — the synthetic chemicals used in everyday products for food packaging, personal care, toys and more — have been linked to abnormal neurological development in infants.

Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.

The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
“This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.

First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.

Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.

“We conducted this study because phthalates are everywhere in our daily lives,” Liang said, hence their nickname “everywhere chemicals.”

Harming infant health
The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.

Within a day or two of birth, the authors collected the babies’ blood via a heel stick.

The team found prenatal phthalate levels were associated with lower levels of tyrosine, an amino acid and precursor to the thyroid hormone thyroxine. Thyroxine was also abnormally low in those with in utero phthalate exposure, and low thyroxine has been previously associated with greater vulnerability to illness and neurodevelopmental issues in newborns, the authors said. Tyrosine is also a precursor to the neurotransmitters dopamine, norepinephrine and epinephrine, all of which partly contribute to the body’s fight-or-flight response. Low levels of these neurotransmitters can lead to various problems, including anxiety, depression and trouble focusing.

Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.

Larrywrida

01 Apr 2025 - 09:02 pm

Бесплатно размещайте объявления и получайте отклики уже в
первые часы. Удобный поиск, актуальные предложения, реальные
люди. Попробуйте сами: Twidoo.su — ваш путь к успеху!

Доска бесплатных объявлений Twidoo.su

Larrywrida

01 Apr 2025 - 09:02 pm

Бесплатно размещайте объявления и получайте отклики уже в
первые часы. Удобный поиск, актуальные предложения, реальные
люди. Попробуйте сами: Twidoo.su — ваш путь к успеху!

Доска бесплатных объявлений Twidoo.su

Larrywrida

01 Apr 2025 - 09:01 pm

Бесплатно размещайте объявления и получайте отклики уже в
первые часы. Удобный поиск, актуальные предложения, реальные
люди. Попробуйте сами: Twidoo.su — ваш путь к успеху!

Доска бесплатных объявлений Twidoo.su

Calibrycasinoapp

01 Apr 2025 - 08:13 pm

[url=https://play.calibri-casino-app.ru/]https://www.play.calibri-casino-app.ru[/url]

Calibry casino
http://www.play.calibri-casino-app.ru

Danielmaw

01 Apr 2025 - 12:44 pm

‘White Lotus’ villain Jon Gries reveals the true crimes that inspired his twisty take on Greg/Gary
fixedfloat
When Season 3 of “The White Lotus” premiered last month, the shock was palpable when returning character Belinda recognized a familiar face at the resort in Thailand: Greg Hunt, the wily suitor of the late Tanya McQuoid.

As the season has unfolded, Greg (played by Jon Gries) has emerged as an antagonist, particularly after Belinda dove into the investigation surrounding Tanya’s death and learned that Greg, who now goes by Gary, evaded questioning by authorities.

On a show famous for reinventing itself, the same has been asked of the actor, who says that playing the ever-shifting character has been a welcome challenge and, like “White Lotus” itself, full of twists.

“In the beginning, I totally played him for a guy who was, you know, on his last legs,” Gries said in a recent interview with CNN, referencing Greg’s very apparent ill health in the first season of “White Lotus,” which premiered to rave reviews in summer 2021. He added: “When you play a character, you want to find his empathetic side, and you want to understand where they came from, and what got them to where they are.”

But when he was contacted by creator Mike White about appearing in Season 2, Gries realized he would have to adjust his framing of Greg, despite having previously imagined a “comprehensive history” for him on his own.

“(White) said, ‘I’m writing it right now, and I’m writing you, and I just need to know here and now: If you’re in, I’ll continue writing. If not, I’ll stop,’” Gries recalled.

Adam

01 Apr 2025 - 12:19 pm

Добро пожаловать на наш сайт – ваше решение для всех финансовых потребностей!
Наши предложения
Мы предлагаем различные финансовые продукты: кредиты, банковские карты и займы, чтобы помочь вам достигнуть ваших целей и осуществить мечты.
карта с высокими процентами на остаток
Идеальные кредиты для ваших нужд
Нуждаетесь в финансировании на покупку жилья, автомобиля или образование? Наши кредитные программы разработаны с учетом ваших потребностей. Оформите кредит на нашем сайте, выбрав подходящие условия и сроки погашения.
Преимущества наших банковских карт
Наши банковские карты предоставляют:
Удобство безналичных платежей
Бонусы и привилегии
Оформите карту на нашем сайте и получайте кэшбэк, скидки у партнеров и участие в программе лояльности. Выберите карту с оптимальными лимитами и условиями обслуживания для себя.
Быстрые и удобные займы
Нужны деньги до зарплаты или на непредвиденные расходы? Наши займы – это быстро и удобно. Мы предлагаем прозрачные условия и мгновенное одобрение заявок, чтобы вы могли решать финансовые вопросы без задержек.
кредитная карта с низким лимитом
Наши преимущества:
Простота и Удобство: Оформите заявку онлайн за несколько минут.
Надежность и Прозрачность: Мы гарантируем честные условия и отсутствие скрытых комиссий.
Индивидуальный Подход: Мы учитываем ваши личные обстоятельства и предлагаем оптимальные условия.
Не упустите возможность улучшить свою финансовую ситуацию! Оформите кредит, банковскую карту или займ на нашем сайте уже сегодня и насладитесь всеми преимуществами сотрудничества с надежным финансовым партнером.
С нами ваши мечты станут реальностью!

Herberttum

01 Apr 2025 - 01:25 am

A tiny rainforest country is growing into a petrostate. A US oil company could reap the biggest rewards
swell
Guyana’s destiny changed in 2015. US fossil fuel giant Exxon discovered nearly 11 billion barrels of oil in the deep water off the coast of this tiny, rainforested country.

It was one of the most spectacular oil discoveries of recent decades. By 2019, Exxon and its partners, US oil company Hess and China-headquartered CNOOC, had started producing the fossil fuel.? They now pump around 650,000 barrels of oil a day, with plans to more than double this to 1.3 million by 2027.

Guyana now has the world’s highest expected oil production growth through 2035.

This country — sandwiched between Brazil, Venezuela and Suriname — has been hailed as a climate champion for the lush, well-preserved forests that carpet nearly 90% of its land. It is on the path to becoming a petrostate at the same time as the impacts of the fossil fuel-driven climate crisis escalate.

While the government says environmental protection and an oil industry can go hand-in-hand, and low-income countries must be allowed to exploit their own resources, critics say it’s a dangerous path in a warming world, and the benefits may ultimately skew toward Exxon — not Guyana.

Carlosberne

01 Apr 2025 - 12:32 am

Mindful wellness challenges
If you’re the type of person who thrives on challenges and pushing your limits, this doesn’t mean you need to shy away from wellness challenges altogether. But before diving in, take a step back and ask yourself if you’re pursuing the challenge for the right reasons, McGregor said.
velodrome finance
Some people want to try these challenges because they believe something is missing from their life, and they’re looking to attain “worth” or receive validation, McGregor noted.

A good way to assess your motivation is by considering whether the challenge will benefit your health or if it’s about showcasing your accomplishments on social media or some other reason.

Before trying any new trend, make sure you have the foundation to handle it and be aware of any potential risks, McGregor said.

For casual runners, this might mean signing up for a 5K but building your endurance gradually while incorporating other strength training exercises into your routine. For more intense challenges, such as a marathon, McGregor encourages people to consult with professionals or a coach who can monitor your progress and condition along the way.

Focusing on sustainable habits
Both McGregor and Curran emphasize the importance of fostering sustainable health habits before embarking on more extreme challenges.

Rather than chasing the idea of being “healthy,” McGregor suggests focusing on actual healthful behaviors and starting small.

If you’re a highly sedentary person and want to add more movement to your day, try doing lunges while brushing your teeth or taking short walks throughout your typical routine.

Anthonyoxilm

01 Apr 2025 - 12:18 am

Scientists redid an experiment that showed how life on Earth could have started. They found a new possibility
safepal
In the 1931 movie “Frankenstein,” Dr. Henry Frankenstein howling his triumph was an electrifying moment in more ways than one. As massive bolts of lightning and energy crackled, Frankenstein’s monster stirred on a laboratory table, its corpse brought to life by the power of electricity.

Electrical energy may also have sparked the beginnings of life on Earth billions of years ago, though with a bit less scenery-chewing than that classic film scene.

Earth is around 4.5 billion years old, and the oldest direct fossil evidence of ancient life — stromatolites, or microscopic organisms preserved in layers known as microbial mats — is about 3.5 billion years old. However, some scientists suspect life originated even earlier, emerging from accumulated organic molecules in primitive bodies of water, a mixture sometimes referred to as primordial soup.

But where did that organic material come from in the first place? Researchers decades ago proposed that lightning caused chemical reactions in ancient Earth’s oceans and spontaneously produced the organic molecules.

Now, new research published March 14 in the journal Science Advances suggests that fizzes of barely visible “microlightning,” generated between charged droplets of water mist, could have been potent enough to cook up amino acids from inorganic material. Amino acids — organic molecules that combine to form proteins — are life’s most basic building blocks and would have been the first step toward the evolution of life.